When brilliant surgeon Ukyo Retsu removes a cancer from a mysterious old woman, he doesn't realize that the cancer is a 5000 year-old demon. Ukyo must then assume the role of protector of the Earth.
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The Rani has returned with another malicious scientific scheme. Taking advantage of the post-regenerative trauma the recently regenerated and unstable Doctor is going through, she hopes to achieve control of an approaching asteroid composed entirely of strange matter. Can the Doctor figure out he is being used for the Rani's evil experiment, and what is behind the door the Rani won't allow him past?
The Time Lords send the Doctor and Jo on a mission to deliver a sealed message pod to an unknown party aboard a Skybase orbiting the planet Solos in the 30th century. They are caught quickly in a power struggle between the cruel Marshal of Solos and the young Solonian Ky over the future of Solos - a future that hinges on the contents of the message.
The Master, in the guise of Professor Thascalos, has constructed at the Newton Institute in Wootton a device known as TOMTIT - Transmission Of Matter Through Interstitial Time - to gain control over Kronos, a creature from outside time. The creature is summoned but proves to be uncontrollable.
The Doctor and Jo find themselves trapped inside an alien peepshow machine which showman Vorg and his assistant Shirna have brought to amuse the populace of the planet Inter Minor. Can they escape Vorg and the ferocious Drashigs?
In the 26th century, the Doctor and Jo uncover a plot by the Master to provoke an interplanetary war between Earth and Draconia.
On the jungle planet Spiridon, the Doctor, Jo and a Thal group find a slumbering army of Daleks ready to awaken.